IMMUNE RESPONSES, THERAPEUTIC ANTI-TUMOR EFFECTS, AND TOLERABILITY UPON THERAPEUTIC HPV16/18 E6/E7 DNA VACCINATION VIA NEEDLE-FREE BIOJECTOR

Immune responses, therapeutic anti-tumor effects, and tolerability upon therapeutic HPV16/18 E6/E7 DNA vaccination via needle-free biojector

ABSTRACT Intramuscular vaccination of mice with the naked pBI-11 DNA plasmid targeting E6 and E7 of HPV16 and HPV18 via a conventional syringe and needle generates human papillomavirus (HPV) antigen-specific CD8+ T cell-mediated immune responses and therapeutic effects against the TC-1 tumor model.However, delivery of DNA vaccines by this method is

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Homogeneous nucleation rates of nitric acid dihydrate (NAD) at simulated stratospheric conditions – Part II: Modelling

Activation energies ΔGact for the nucleation of nitric acid dihydrate (NAD) in supercooled binary HNO3/H2O solution droplets were calculated from volume-based nucleation rate measurements using the AIDA (Aerosol, Interactions, and Dynamics in the Atmosphere) aerosol chamber of Forschungszentrum Karlsruhe.The experimental conditions covered te

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Nitrogenous compounds characterized in the deterrent skin extract of migratory adult sea lamprey from the Great Lakes region.

The sea lamprey (Petromzons marinus) is a devastating invasive species that represents a significant classic carlectables - recent releases impediment to restoration of the Laurentian Great Lakes.There is substantial interest in developing environmentally benign control strategies for sea lamprey, and many other aquatic invasive species, that emplo

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